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5.18 Intense Hypotension Promethazine HCl and codeine phosphate oral Alternative might result in extreme hypotension which include orthostatic hypotension and syncope in ambulatory people. There's elevated risk in patients whose ability to maintain hypertension has by now been compromised by a minimized blood volume or concurrent administration of specific CNS depressant medication (e.

While critical, lifetime-threatening, or deadly respiratory melancholy can come about at any time for the duration of the usage of promethazine HCl and codeine phosphate oral Option, the danger is greatest throughout the initiation of therapy, when promethazine HCl and codeine phosphate oral Remedy is utilized concomitantly with other drugs that could lead to respiratory depression [see Warnings and Safeguards (5.

If this SPL has inactivated NDCs detailed with the FDA initiated compliance action, They are going to be specified therefore.

Position the combination inside a container for instance a sealed plastic bag and throw it away inside the house trash. You can even stick to your point out or community suggestions on how to safely throw absent Promethazine Hydrochloride and Codeine Phosphate Oral Answer.

The codeine in promethazine HCl and codeine phosphate oral solution may well result in constipation or obstructive bowel disorder, specifically in patients with underlying intestinal motility Problems. Use with warning in sufferers with fundamental intestinal motility Problems.

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Promethazine Signs and signs and symptoms of overdosage with promethazine range from delicate despair on the central anxious process and cardiovascular technique to profound hypotension, respiratory depression, unconsciousness and sudden Demise.

MAOI Conversation Inform clients not to just take promethazine HCl and codeine phosphate oral Answer whilst using or inside of 14 days of halting any medication that inhibit monoamine oxidase.

Everyday living-threatening respiratory despair and Loss of life have happened in children who been given codeine. A lot of the documented situations transpired adhering to tonsillectomy and/or adenoidectomy, and plenty of of the children experienced evidence of currently being an ultra-fast metabolizer of codeine on account of a CYP2D6 polymorphism [see Warnings and Precautions (five.three)]. Promethazine HCl and codeine phosphate oral Option is contraindicated in little ones more youthful than twelve several years of age As well as in young children younger than 18 yrs of age subsequent tonsillectomy and/or adenoidectomy [see Contraindications (four)].

This tends to occur Even though you website take Promethazine Hydrochloride and Codeine Phosphate Oral Alternative particularly as prescribed by your healthcare company. Your risk of dependancy, abuse, and misuse is increased should you or perhaps a member of the family contains a heritage of drug or Alcoholic beverages abuse or habit, or psychological health conditions.

There are no readily available information with promethazine HCl and codeine phosphate oral Alternative use in Expecting Females to inform a drug-affiliated danger for adverse developmental outcomes.

Concentration–Adverse Response Interactions There is a romance concerning rising codeine plasma focus and increasing frequency of dose-related opioid adverse reactions for example nausea, vomiting, CNS outcomes, and respiratory despair.

Impaired secretion from sweat glands following poisonous doses of prescription drugs with anticholinergic Unwanted effects could predispose to hyperthermia.